Here are Saturday’s matchups in the Top 25 this week:
| Away | Home | Spread | Time | TV |
| Marshall | #3 Ohio State | OSU -40 | 12:00 PM | FOX |
| NC State | #21 Clemson | CLEM -18.5 | 12:00 PM | ABC |
| Arkansas State | #20 Iowa State | ISU -21 | 2:00 PM | ESPN+ |
| Kent State | #10 Penn State | PSU -49 | 3:30 PM | BTN |
| #11 USC | #18 Michigan | USC -4 | 3:30 PM | CBS |
| UCLA | #16 LSU | LSU -22.5 | 3:30 PM | ABC |
| Miami (OH) | #17 Notre Dame | ND -28 | 3:30 PM | NBC |
| Georgia Tech | #19 Louisville | LOU -10 | 3:30 PM | ESPN2 |
| Buffalo | #23 N. Illinois | NIU -13.5 | 3:30 PM | ESPN+ |
| #12 Utah | #14 Oklahoma State | Utah -1 | 4:00 PM | FOX |
| Vanderbilt | #7 Missouri | MIZZOU -20 | 4:15 PM | SECN |
| #8 Miami | South Florida | MIAMI -17 | 7:00 PM | ESPN |
| #6 Tennessee | #15 Oklahoma | TENN -6.5 | 7:30 PM | ABC |
| Bowling Green | #25 Texas A&M | TXAM -22.5 | 7:30 PM | ESPN+ |
| GA Southern | #5 Ole Miss | MISS -34.5 | 7:45 PM | SECN |
| UL Monroe | #1 Texas | TEX -44 | 8:00 PM | ESPN+ |
| #13 Kansas State | BYU | KSU -7 | 10:30 PM | ESPN |
Spreads from ESPN Bet as of 09/20/2024